Cystatin C and neutrophil gelatinase-associated lipocalin (NGAL) as novel biomarkers for monitoring acute kidney injury after cardiac surgery
نویسندگان
چکیده
Background Acute kidney injury (AKI) occurs frequently after cardiac surgery using cardiopulmonary bypass (CPB). Conventional markers of kidney function like creatinine and potassium concentration are unreliable indicators during acute changes in kidney function and demonstrate injury late in the clinical course. Therefore, in the search of more sensitive biomarkers for monitoring AKI following cardiac surgery we tested if cystatin C and neutrophil gelatinase-associated lipocalin (NGAL) measured after surgery would characterize AKI early after CPB.
منابع مشابه
Comparative Assessment of Neutrophil Gelatinase-Associated Lipocalin (NGAL) and Cystatin C as Early Biomarkers for Early Detection of Renal Failure in Patients with Hypertension
Background: Hypertension is one the most common causes of chronic kidney disease (CKD). One of the major concerns in hypertensive patients is early detection of renal disorders. In the past, serum creatinine (Scr) concentration was used as a marker of kidney function, but it proffers a late reflection of reduced glomerular filtration rate. Cystatin C and neutrophil gelatinase-associated lipocal...
متن کاملCystatin C and neutrophil gelatinase-associated lipocalin: biomarkers for acute kidney injury after congenital heart surgery.
QUESTIONS UNDER STUDY To evaluate the diagnostic value of serum Cystatin C and urine neutrophil gelatinase-associated lipocalin (NGAL) for the detection of acute kidney injury in patients undergoing congenital heart surgery. METHODS Serial samples of serum Cystatin C and urine NGAL were collected from 139 consecutive patients with congenital heart defects aged 3 days to 30 years after admissi...
متن کاملAssessing the Prediction Power of Plasma Neutrophil Gelatinase-Associated Lipocalin and Serum Cystatin C for Diagnosis Kidney Damage
Background & Objective: Chronic Kidney Disease (CKD) has been recognized as a serious public health threat. The early detection of kidney damage in CKD is a useful way to reduce the disease burden. This study aimed to determine the power of Neutrophil gelatinase-associated lipocalin (NGAL) and cystatin C (Cys-C) to predict the kidney damage in Iranian patients. Materials & Methods: This st...
متن کاملValue of Plasma/Serum Neutrophil Gelatinase-Associated Lipocalin in Detection of Pediatric Acute Kidney Injury; a Systematic Review and Meta-Analysis
Background: Major attention has been drawn to the prognostic value of plasma/serum neutrophil gelatinase-associated lipocalin (NGAL) in detection of acute kidney injury (AKI) in children, but still no consensus has been reached. Accordingly, the present study aimed to assess the diagnostic value of this biomarker in detection of acute kidney injury in children through a systematic review and me...
متن کاملA novel use for novel acute kidney injury biomarkers: fenoldopam's effect on neutrophil gelatinase-associated lipocalin and cystatin C
Substantial basic and translational research has been directed to detect earlier and more sensitive acute kidney injury (AKI) biomarkers over the past decade. Much of the seminal AKI biomarker validation research has been performed in children undergoing cardiopulmonary bypass since they represent an ideal clinical model for AKI biomarker study: the timing of the injury is known and children do...
متن کامل